Photos of Star's Post-Ozempic Body Prove Worst Fears for Side Effects
What this video covers
This is a short clip from Dave Rubin’s Rubin Report, excerpting a segment of the “Actual Friends” podcast — the roundtable Rubin co-hosts with Jillian Michaels, Sage Steele, and Dr. Drew Pinsky. The topic is GLP-1 weight-loss drugs, specifically Ozempic, and the segment is framed around celebrity photos: the hosts discuss Demi Moore’s recent appearance, which Rubin describes as “creepy” and frail, and present it as a cautionary example of what they argue are the drugs’ frightening side effects.
The format is a highlight reel rather than a full discussion — five and a half minutes built for sharing, with the clip’s title making the channel’s editorial claim up front (“prove worst fears”). The panel’s argument, as presented in the clip, is that the visible physical changes in celebrities using the drugs should serve as a warning to the public as use spreads. The video description points viewers to the full “Actual Friends” episode for the longer conversation.
Note on sourcing: this video is Rubin’s edit and framing of the roundtable, posted to his channel — the title’s claim that the photos “prove” the side-effect fears is the channel’s characterization, not an established medical finding. The underlying full-length discussion lives on the Actual Friends feed.
Key points
- The clip is an excerpt from the “Actual Friends” podcast roundtable: Dave Rubin, Jillian Michaels, Sage Steele, and Dr. Drew.
- The panel discusses what they describe as the real dangers of Ozempic and GLP-1 drugs, per the channel’s framing.
- Demi Moore’s recent appearance is held up by the hosts as a visible warning — Rubin calls it “creepy” and frail; the segment opens on her 2026 Cannes red-carpet photos, with Rubin saying “you could say she looks like a skeleton.”
- Dr. Drew’s specific contribution, per the transcript: he says he is “gravely concerned” about muscle loss associated with GLP-1 drugs, arguing that muscle metabolism is one of the key ingredients in longevity and overall metabolic health — his medical framing, presented as his view.
- The argument presented is that more celebrities are showing what the panel characterizes as frightening side effects of the drugs.
- The clip format is a shareable highlight; the full discussion is linked on the Actual Friends channel.
- The title’s claim that the photos “prove” the worst fears about side effects is the Rubin Report’s editorial framing, not a medical conclusion stated in the site’s voice.