Jay Bhattacharya on Alzheimer's groupthink around the amyloid hypothesis: warns against

Bhattacharya warns against the Alzheimer’s field’s devotion to the amyloid hypothesis, citing what he called the “research integrity scandal” in the area. At his March 2025 nomination hearing, according to The Star News Network’s reporting, he argued that devotion to the amyloid hypothesis — possibly built on falsified data — crowded out study of other explanations for Alzheimer’s. His stated reasoning is that a dominant paradigm, enforced by funding and prestige incentives, can lock an entire field into chasing a hypothesis that may not hold up, delaying progress on alternative explanations. The underlying research-integrity scandal is a matter of public record; the degree to which the amyloid hypothesis itself is undermined remains contested among scientists, and this site presents Bhattacharya’s assessment as his view.

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